3T04
Crystal structure of monobody 7c12/abl1 sh2 domain complex
Summary for 3T04
Entry DOI | 10.2210/pdb3t04/pdb |
Descriptor | Tyrosine-protein kinase ABL1, MONOBODY 7C12, GLYCEROL, ... (5 entities in total) |
Functional Keywords | engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, atp-binding, phosphoprotein, tyrosine-protein kinase, signaling protein-protein binding complex, signaling protein/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 2 |
Total formula weight | 25465.86 |
Authors | Wojcik, J.B.,Wyrzucki, A.M.,Koide, S. (deposition date: 2011-07-19, release date: 2011-11-23, Last modification date: 2023-09-13) |
Primary citation | Grebien, F.,Hantschel, O.,Wojcik, J.,Kaupe, I.,Kovacic, B.,Wyrzucki, A.M.,Gish, G.D.,Cerny-Reiterer, S.,Koide, A.,Beug, H.,Pawson, T.,Valent, P.,Koide, S.,Superti-Furga, G. Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147:306-319, 2011 Cited by PubMed: 22000011DOI: 10.1016/j.cell.2011.08.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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