3T04

Crystal structure of monobody 7c12/abl1 sh2 domain complex

3T04 の概要

• エントリーDOI: 10.2210/pdb3t04/pdb
• 分子名称: Tyrosine-protein kinase ABL1, MONOBODY 7C12, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, atp-binding, phosphoprotein, tyrosine-protein kinase, signaling protein-protein binding complex, signaling protein/protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25465.86

構造登録者

Wojcik, J.B.,Wyrzucki, A.M.,Koide, S. (登録日: 2011-07-19, 公開日: 2011-11-23, 最終更新日: 2023-09-13)

• 主引用文献: Grebien, F.,Hantschel, O.,Wojcik, J.,Kaupe, I.,Kovacic, B.,Wyrzucki, A.M.,Gish, G.D.,Cerny-Reiterer, S.,Koide, A.,Beug, H.,Pawson, T.,Valent, P.,Koide, S.,Superti-Furga, G.; Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis.; Cell(Cambridge,Mass.), 147:306-319, 2011; PubMed: 22000011; DOI: 10.1016/j.cell.2011.08.046

実験手法

X-RAY DIFFRACTION (2.1 Å)