3T03

Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16

3T03 の概要

• エントリーDOI: 10.2210/pdb3t03/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, (5Z)-5-(5-bromo-2-methoxybenzylidene)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione, ... (4 entities in total)
• 機能のキーワード: protein-drug complex, thiazolidinediones, ligand binding protein, transcription factor, nucleus receptor, transcription-transcription regulator complex, transcription/transcription regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69874.53

構造登録者

Rajagopalan, S.,Webb, P.,Baxter, J.D.,Brennan, R.G.,Phillips, K.J. (登録日: 2011-07-19, 公開日: 2012-05-23, 最終更新日: 2023-09-13)

• 主引用文献: Amato, A.A.,Rajagopalan, S.,Lin, J.Z.,Carvalho, B.M.,Figueira, A.C.,Lu, J.,Ayers, S.D.,Mottin, M.,Silveira, R.L.,Souza, P.C.,Mourao, R.H.,Saad, M.J.,Togashi, M.,Simeoni, L.A.,Abdalla, D.S.,Skaf, M.S.,Polikparpov, I.,Lima, M.C.,Galdino, S.L.,Brennan, R.G.,Baxter, J.D.,Pitta, I.R.,Webb, P.,Phillips, K.J.,Neves, F.A.; GQ-16, a novel peroxisome proliferator-activated receptor (PPAR gamma) ligand, promotes insulin sensitization without weight gain.; J.Biol.Chem., 287:28169-28179, 2012; PubMed: 22584573; DOI: 10.1074/jbc.M111.332106

実験手法

X-RAY DIFFRACTION (2.1 Å)