3SZB
Crystal structure of human ALDH3A1 modified with the beta-elimination product of Aldi-1; 1-phenyl- 2-propen-1-one
Summary for 3SZB
Entry DOI | 10.2210/pdb3szb/pdb |
Related | 3SZ9 3SZA |
Descriptor | Aldehyde dehydrogenase, POTASSIUM ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | aldh, aldi-1, inhibitor, rossmann fold, covalent adduct, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P30838 |
Total number of polymer chains | 2 |
Total formula weight | 105034.31 |
Authors | Khanna, M.,Hurley, T.D. (deposition date: 2011-07-18, release date: 2011-11-02, Last modification date: 2023-09-13) |
Primary citation | Khanna, M.,Chen, C.H.,Kimble-Hill, A.,Parajuli, B.,Perez-Miller, S.,Baskaran, S.,Kim, J.,Dria, K.,Vasiliou, V.,Mochly-Rosen, D.,Hurley, T.D. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J.Biol.Chem., 286:43486-43494, 2011 Cited by PubMed: 22021038DOI: 10.1074/jbc.M111.293597 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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