3SYM
Glycogen Phosphorylase b in complex with 3 -C-(hydroxymethyl)-beta-D-glucopyranonucleoside of 5-fluorouracil
Summary for 3SYM
Entry DOI | 10.2210/pdb3sym/pdb |
Related | 3SYR |
Descriptor | Glycogen phosphorylase, muscle form, 5-fluoro-1-[3-C-(hydroxymethyl)-beta-D-glucopyranosyl]pyrimidine-2,4(1H,3H)-dione (3 entities in total) |
Functional Keywords | alpha and beta protein, transferase-transferase inhibitor complex, muscle, transferase, glycogen metabolism, transferase/transferase inhibitor |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Total number of polymer chains | 1 |
Total formula weight | 97841.56 |
Authors | Skamnaki, V.T.,Katsandi, A.L.,Kontou, M.,Leonidas, D.D. (deposition date: 2011-07-18, release date: 2012-02-15, Last modification date: 2020-07-29) |
Primary citation | Manta, S.,Xipnitou, A.,Kiritsis, C.,Kantsadi, A.L.,Hayes, J.M.,Skamnaki, V.T.,Lamprakis, C.,Kontou, M.,Zoumpoulakis, P.,Zographos, S.E.,Leonidas, D.D.,Komiotis, D. 3'-Axial CH(2) OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why. Chem.Biol.Drug Des., 79:663-673, 2012 Cited by PubMed: 22296957DOI: 10.1111/j.1747-0285.2012.01349.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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