3SWZ
Human Cytochrome P450 17A1 in complex with TOK-001
Summary for 3SWZ
Entry DOI | 10.2210/pdb3swz/pdb |
Related | 3RUK |
Descriptor | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,8alpha)-17-(1H-benzimidazol-1-yl)androsta-5,16-dien-3-ol, ... (4 entities in total) |
Functional Keywords | cytochrome p450, p450, cyp17a1, p450c17, p450 17a1, monooxygenase, 17a-hydroxylase, 17, 20-lyase, heme protein, cytochrome p450 oxidoreductase, galeterone, membrane, tok-001, vn/124-1, microsome, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane : P05093 |
Total number of polymer chains | 4 |
Total formula weight | 226980.69 |
Authors | DeVore, N.M.,Scott, E.E. (deposition date: 2011-07-14, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Devore, N.M.,Scott, E.E. Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature, 482:116-119, 2012 Cited by PubMed: 22266943DOI: 10.1038/nature10743 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report