3SWZ

Human Cytochrome P450 17A1 in complex with TOK-001

3SWZ の概要

• エントリーDOI: 10.2210/pdb3swz/pdb
• 関連するPDBエントリー: 3RUK
• 分子名称: Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,8alpha)-17-(1H-benzimidazol-1-yl)androsta-5,16-dien-3-ol, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, p450, cyp17a1, p450c17, p450 17a1, monooxygenase, 17a-hydroxylase, 17, 20-lyase, heme protein, cytochrome p450 oxidoreductase, galeterone, membrane, tok-001, vn/124-1, microsome, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane : P05093
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 226980.69

構造登録者

DeVore, N.M.,Scott, E.E. (登録日: 2011-07-14, 公開日: 2012-01-25, 最終更新日: 2023-09-13)

• 主引用文献: Devore, N.M.,Scott, E.E.; Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.; Nature, 482:116-119, 2012; PubMed: 22266943; DOI: 10.1038/nature10743

実験手法

X-RAY DIFFRACTION (2.4 Å)