3SU4
Crystal structure of NS3/4A protease variant R155K in complex with vaniprevir
Summary for 3SU4
Entry DOI | 10.2210/pdb3su4/pdb |
Related | 3SU3 3SU5 3SU6 3SUD 3SUE 3SUF 3SUG 3SV6 3SV7 3SV8 3SV9 |
Descriptor | NS3 protease,NS4A protein, (5R,7S,10S)-10-tert-butyl-N-{(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethylcyclopropyl}-15,15-dimethyl-3,9,12-trioxo-6,7,9,10,11,12,14,15,16,17,18,19-dodecahydro-1H,5H-2,23:5,8-dimethano-4,13,2,8,11-benzodioxatriazacyclohenicosine-7(3H)-carboxamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | drug resistance, drug design, protease inhibitors, serine protease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Hepatitis C virus subtype 1a More |
Total number of polymer chains | 2 |
Total formula weight | 44757.45 |
Authors | Schiffer, C.A.,Romano, K.P. (deposition date: 2011-07-11, release date: 2012-09-05, Last modification date: 2024-02-28) |
Primary citation | Romano, K.P.,Ali, A.,Aydin, C.,Soumana, D.,Ozen, A.,Deveau, L.M.,Silver, C.,Cao, H.,Newton, A.,Petropoulos, C.J.,Huang, W.,Schiffer, C.A. The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors. Plos Pathog., 8:e1002832-e1002832, 2012 Cited by PubMed: 22910833DOI: 10.1371/journal.ppat.1002832 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.255 Å) |
Structure validation
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