3STK

Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP)

Summary for 3STK

Entry DOI	10.2210/pdb3stk/pdb
Related	3STM 3STN
Descriptor	Fatty acid-binding protein, liver, PALMITIC ACID (3 entities in total)
Functional Keywords	lfabp, palmitic acid, fatty acid binding, lipid binding protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07148
Total number of polymer chains	1
Total formula weight	15112.58
Authors	Sharma, A.,Sharma, A. (deposition date: 2011-07-11, release date: 2011-08-10, Last modification date: 2024-03-20)
Primary citation	Sharma, A.,Sharma, A. Fatty acid induced remodeling within the Human liver fatty acid binding protein J.Biol.Chem., 2011 Cited by PubMed Abstract: We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling, where the first palmitate ingress creates the atomic environment for placement of the second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP. PubMed: 21757748 DOI: 10.1074/jbc.M111.270165 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation