3STK

Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP)

3STK の概要

• エントリーDOI: 10.2210/pdb3stk/pdb
• 関連するPDBエントリー: 3STM 3STN
• 分子名称: Fatty acid-binding protein, liver, PALMITIC ACID (3 entities in total)
• 機能のキーワード: lfabp, palmitic acid, fatty acid binding, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07148
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15112.58

構造登録者

Sharma, A.,Sharma, A. (登録日: 2011-07-11, 公開日: 2011-08-10, 最終更新日: 2024-03-20)

主引用文献

Sharma, A.,Sharma, A.
Fatty acid induced remodeling within the Human liver fatty acid binding protein
J.Biol.Chem., 2011

PubMed Abstract: We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling, where the first palmitate ingress creates the atomic environment for placement of the second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP.

PubMed: 21757748
DOI: 10.1074/jbc.M111.270165

実験手法

X-RAY DIFFRACTION (1.55 Å)