3SRS
S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines
Summary for 3SRS
Entry DOI | 10.2210/pdb3srs/pdb |
Related | 3SQY 3SR5 3SRQ 3SRR 3SRU 3SRW |
Descriptor | Dihydrofolate reductase, 7-(5-bromo-2-ethoxyphenyl)-6-methylquinazoline-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | dihydrofolate reductase, dhfr, drug design, enzyme inhibitors, folate, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 20463.74 |
Authors | Hilgers, M. (deposition date: 2011-07-07, release date: 2011-08-31, Last modification date: 2024-02-28) |
Primary citation | Li, X.,Hilgers, M.,Cunningham, M.,Chen, Z.,Trzoss, M.,Zhang, J.,Kohnen, L.,Lam, T.,Creighton, C.,G C, K.,Nelson, K.,Kwan, B.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J. Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21:5171-5176, 2011 Cited by PubMed: 21831637DOI: 10.1016/j.bmcl.2011.07.059 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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