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3SRQ

S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines

Summary for 3SRQ
Entry DOI10.2210/pdb3srq/pdb
Related3SQY 3SR5 3SRR 3SRS 3SRU 3SRW
DescriptorDihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-[3-(2,4-diamino-6-methylquinazolin-7-yl)phenyl]ethanone, ... (4 entities in total)
Functional Keywordsdihydrofolate reductase, dhfr, drug design, enzyme inhibitors, folate, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total formula weight20382.83
Authors
Hilgers, M. (deposition date: 2011-07-07, release date: 2011-08-31, Last modification date: 2024-02-28)
Primary citationLi, X.,Hilgers, M.,Cunningham, M.,Chen, Z.,Trzoss, M.,Zhang, J.,Kohnen, L.,Lam, T.,Creighton, C.,G C, K.,Nelson, K.,Kwan, B.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J.
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
Bioorg.Med.Chem.Lett., 21:5171-5176, 2011
Cited by
PubMed: 21831637
DOI: 10.1016/j.bmcl.2011.07.059
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

217705

건을2024-03-27부터공개중

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