3SQO
PCSK9 J16 Fab complex
Summary for 3SQO
Entry DOI | 10.2210/pdb3sqo/pdb |
Descriptor | Proprotein convertase subtilisin/kexin type 9, J16 Heavy chain, J16 Light chain, ... (5 entities in total) |
Functional Keywords | cholesterol regulation, ldlr, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: Q8NBP7 Q8NBP7 |
Total number of polymer chains | 4 |
Total formula weight | 118530.84 |
Authors | |
Primary citation | Liang, H.,Chaparro-Riggers, J.,Strop, P.,Geng, T.,Sutton, J.E.,Tsai, D.,Bai, L.,Abdiche, Y.,Dilley, J.,Yu, J.,Wu, S.,Chin, S.M.,Lee, N.A.,Rossi, A.,Lin, J.C.,Rajpal, A.,Pons, J.,Shelton, D.L. Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates. J.Pharmacol.Exp.Ther., 340:228-236, 2012 Cited by PubMed: 22019884DOI: 10.1124/jpet.111.187419 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report