3SQF
Crystal structure of monomeric M-PMV retroviral protease
Summary for 3SQF
| Entry DOI | 10.2210/pdb3sqf/pdb |
| Related | 1NSO 1YTH 2FMB 2RSP 3HVP 3LIY 3NR6 4FIV 4HVP |
| Descriptor | Protease (2 entities in total) |
| Functional Keywords | folded monomer, retroviral protease folded as a monomer, hydrolase, aspartic protease, retroviral protease, retropepsin, d-type retrovirus |
| Biological source | Mason-Pfizer monkey virus |
| Total number of polymer chains | 2 |
| Total formula weight | 25799.67 |
| Authors | Jaskolski, M.,Kazmierczyk, M.,Gilski, M.,Krzywda, S.,Pichova, I.,Zabranska, H.,Khatib, F.,DiMaio, F.,Cooper, S.,Thompson, J.,Popovic, Z.,Baker, D.,Group, Foldit Contenders (deposition date: 2011-07-05, release date: 2011-09-21, Last modification date: 2023-09-13) |
| Primary citation | Khatib, F.,DiMaio, F.,Cooper, S.,Kazmierczyk, M.,Gilski, M.,Krzywda, S.,Zabranska, H.,Pichova, I.,Thompson, J.,Popovic, Z.,Jaskolski, M.,Baker, D. Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat.Struct.Mol.Biol., 18:1175-1177, 2011 Cited by PubMed Abstract: Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs. PubMed: 21926992DOI: 10.1038/nsmb.2119 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6324 Å) |
Structure validation
Download full validation report
