3SQF

Crystal structure of monomeric M-PMV retroviral protease

3SQF の概要

• エントリーDOI: 10.2210/pdb3sqf/pdb
• 関連するPDBエントリー: 1NSO 1YTH 2FMB 2RSP 3HVP 3LIY 3NR6 4FIV 4HVP
• 分子名称: Protease (2 entities in total)
• 機能のキーワード: folded monomer, retroviral protease folded as a monomer, hydrolase, aspartic protease, retroviral protease, retropepsin, d-type retrovirus
• 由来する生物種: Mason-Pfizer monkey virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25799.67

構造登録者

Jaskolski, M.,Kazmierczyk, M.,Gilski, M.,Krzywda, S.,Pichova, I.,Zabranska, H.,Khatib, F.,DiMaio, F.,Cooper, S.,Thompson, J.,Popovic, Z.,Baker, D.,Group, Foldit Contenders (登録日: 2011-07-05, 公開日: 2011-09-21, 最終更新日: 2023-09-13)

主引用文献

Khatib, F.,DiMaio, F.,Cooper, S.,Kazmierczyk, M.,Gilski, M.,Krzywda, S.,Zabranska, H.,Pichova, I.,Thompson, J.,Popovic, Z.,Jaskolski, M.,Baker, D.
Crystal structure of a monomeric retroviral protease solved by protein folding game players.
Nat.Struct.Mol.Biol., 18:1175-1177, 2011

PubMed Abstract: Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.

PubMed: 21926992
DOI: 10.1038/nsmb.2119

実験手法

X-RAY DIFFRACTION (1.6324 Å)