3SQ6

Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera with its Agonist Epibatidine

Summary for 3SQ6

• Entry DOI: 10.2210/pdb3sq6/pdb
• Related: 3SQ9
• Descriptor: Neuronal acetylcholine receptor subunit alpha-7, Acetylcholine-binding protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EPIBATIDINE, ... (5 entities in total)
• Functional Keywords: nicotinic receptor, transport protein-receptor-agonist complex, transport protein/receptor/agonist
• Biological source: Homo sapiens, Lymnaea stagnalis (human, great pond snail)
• Total number of polymer chains: 10
• Total formula weight: 241794.87

Authors

Li, S.-X.,Huang, S.,Bren, N.,Noridomi, K.,Dellisanti, C.,Sine, S.,Chen, L. (deposition date: 2011-07-05, release date: 2011-09-28, Last modification date: 2020-07-29)

• Primary citation: Li, S.X.,Huang, S.,Bren, N.,Noridomi, K.,Dellisanti, C.D.,Sine, S.M.,Chen, L.; Ligand-binding domain of an alpha 7-nicotinic receptor chimera and its complex with agonist.; Nat.Neurosci., 14:1253-1259, 2011; PubMed: 21909087; DOI: 10.1038/nn.2908

Experimental method

X-RAY DIFFRACTION (2.8 Å)