3SOR

Factor XIa in complex with a clorophenyl-tetrazole inhibitor

3SOR の概要

• エントリーDOI: 10.2210/pdb3sor/pdb
• 分子名称: Coagulation factor XI, CITRIC ACID, {4-[(N-{3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}-L-phenylalanyl)amino]phenyl}acetic acid, ... (4 entities in total)
• 機能のキーワード: hydrolase, serine protease, coagulation factor, syntethic inhibitor, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P03951
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27581.60

構造登録者

Kazemier, B.,Oubrie, A. (登録日: 2011-06-30, 公開日: 2012-04-11, 最終更新日: 2024-04-03)

• 主引用文献: Fradera, X.,Kazemier, B.,Carswell, E.,Cooke, A.,Oubrie, A.,Hamilton, W.,Dempster, M.,Krapp, S.,Nagel, S.,Jestel, A.; High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.; Acta Crystallogr.,Sect.F, 68:404-408, 2012; PubMed: 22505407; DOI: 10.1107/S1744309112009037

実験手法

X-RAY DIFFRACTION (1.8 Å)