3SOC

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin

Summary for 3SOC

• Entry DOI: 10.2210/pdb3soc/pdb
• Related: 3Q4T
• Descriptor: Activin receptor type-2A, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: structural genomics consortium, sgc, transferase, protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P27037
• Total number of polymer chains: 2
• Total formula weight: 74543.15

Authors

Chaikuad, A.,Williams, E.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Muniz, J.R.C.,Yue, W.W.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-30, release date: 2011-07-20, Last modification date: 2023-09-13)

• Primary citation: Chaikuad, A.,Williams, E.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Muniz, J.R.C.,Yue, W.W.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC); Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin; To be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)