3SOC

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin

3SOC の概要

• エントリーDOI: 10.2210/pdb3soc/pdb
• 関連するPDBエントリー: 3Q4T
• 分子名称: Activin receptor type-2A, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, transferase, protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P27037
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74543.15

構造登録者

Chaikuad, A.,Williams, E.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Muniz, J.R.C.,Yue, W.W.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (登録日: 2011-06-30, 公開日: 2011-07-20, 最終更新日: 2023-09-13)

• 主引用文献: Chaikuad, A.,Williams, E.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Muniz, J.R.C.,Yue, W.W.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC); Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin; To be Published,

実験手法

X-RAY DIFFRACTION (1.95 Å)