3SNB

Crystal structure of SARS coronavirus main protease complexed with Ac-DSFDQ-H (soaking)

3SNB の概要

• エントリーDOI: 10.2210/pdb3snb/pdb
• 関連するPDBエントリー: 2h2z 3SN8 3SNA 3SNC 3SND 3SNE
• 関連するBIRD辞書のPRD_ID: PRD_001118
• 分子名称: 3C-like proteinase, Peptide aldehyde inhibitor Ac-DSFDQ-H (3 entities in total)
• 機能のキーワード: 3c-like proteinase, protease, ac-dsfdq-h, covalent bound, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: SARS coronavirus (SARS-CoV)
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34499.26

構造登録者

Zhu, L.,Hilgenfeld, R. (登録日: 2011-06-29, 公開日: 2011-09-07, 最終更新日: 2012-12-12)

• 主引用文献: Zhu, L.,George, S.,Schmidt, M.F.,Al-Gharabli, S.I.,Rademann, J.,Hilgenfeld, R.; Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.; Antiviral Res., 92:204-212, 2011; PubMed: 21854807; DOI: 10.1016/j.antiviral.2011.08.001

実験手法

X-RAY DIFFRACTION (2.4 Å)