3SN8
Crystal structure of SARS coronavirus main protease complexed with Cm-FF-H (soaking)
Summary for 3SN8
| Entry DOI | 10.2210/pdb3sn8/pdb |
| Related | 2H2Z 3SNA 3SNB 3SNC 3SND 3SNE |
| Related PRD ID | PRD_001114 |
| Descriptor | 3C-like proteinase, N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide (3 entities in total) |
| Functional Keywords | 3c-like proteinase, protease, cm-ff-h, active site, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | SARS coronavirus (SARS-CoV) |
| Cellular location | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8 |
| Total number of polymer chains | 1 |
| Total formula weight | 34305.16 |
| Authors | Zhu, L.,Hilgenfeld, R. (deposition date: 2011-06-29, release date: 2011-09-07, Last modification date: 2012-12-12) |
| Primary citation | Zhu, L.,George, S.,Schmidt, M.F.,Al-Gharabli, S.I.,Rademann, J.,Hilgenfeld, R. Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92:204-212, 2011 Cited by PubMed: 21854807DOI: 10.1016/j.antiviral.2011.08.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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