3SMQ

Crystal structure of protein arginine methyltransferase 3

3SMQ の概要

• エントリーDOI: 10.2210/pdb3smq/pdb
• 分子名称: Protein arginine N-methyltransferase 3, 1-(1,2,3-benzothiadiazol-6-yl)-3-[2-(cyclohex-1-en-1-yl)ethyl]urea, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: structural genomics, structural genomics consortium, sgc, prmt3, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: O60678
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38619.76

構造登録者

Dobrovetsky, E.,Dong, A.,Walker, J.R.,Siarheyeva, A.,Senisterra, G.,Wasney, G.A.,Smil, D.,Bolshan, Y.,Nguyen, K.T.,Allali-Hassani, A.,Hajian, T.,Poda, G.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Al-Awar, R.,Brown, P.J.,Schapira, M.,Arrowsmith, C.H.,Vedadi, M.,Structural Genomics Consortium (SGC) (登録日: 2011-06-28, 公開日: 2011-08-31, 最終更新日: 2023-09-13)

• 主引用文献: Siarheyeva, A.,Senisterra, G.,Allali-Hassani, A.,Dong, A.,Dobrovetsky, E.,Wasney, G.A.,Chau, I.,Marcellus, R.,Hajian, T.,Liu, F.,Korboukh, I.,Smil, D.,Bolshan, Y.,Min, J.,Wu, H.,Zeng, H.,Loppnau, P.,Poda, G.,Griffin, C.,Aman, A.,Brown, P.J.,Jin, J.,Al-Awar, R.,Arrowsmith, C.H.,Schapira, M.,Vedadi, M.; An allosteric inhibitor of protein arginine methyltransferase 3.; Structure, 20:1425-1435, 2012; PubMed: 22795084; DOI: 10.1016/j.str.2012.06.001

実験手法

X-RAY DIFFRACTION (2 Å)