3SM2

The crystal structure of XMRV protease complexed with Amprenavir

Summary for 3SM2

• Entry DOI: 10.2210/pdb3sm2/pdb
• Related: 3NR6 3SLZ 3SM1
• Descriptor: gag-pro-pol polyprotein, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total)
• Functional Keywords: beta-sheet, protease, amprenavir, virus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: DG-75 Murine leukemia virus
• Total number of polymer chains: 2
• Total formula weight: 29196.21

Authors

Li, M.,Gustchina, A.,Wlodawer, A. (deposition date: 2011-06-27, release date: 2011-10-12, Last modification date: 2024-03-13)

• Primary citation: Li, M.,Gustchina, A.,Matuz, K.,Tozser, J.,Namwong, S.,Goldfarb, N.E.,Dunn, B.M.,Wlodawer, A.; Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.; Febs J., 278:4413-4424, 2011; PubMed: 21951660; DOI: 10.1111/j.1742-4658.2011.08364.x

Experimental method

X-RAY DIFFRACTION (1.75 Å)