3SK3

Crystal structure of Salmonella typhimurium acetate kinase (AckA) with citrate bound at the dimeric interface

3SK3 の概要

• エントリーDOI: 10.2210/pdb3sk3/pdb
• 関連するPDBエントリー: 1G99 1SAZ 2E1Y 2IIR 3KHY 3P4I
• 分子名称: Acetate kinase, CITRIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: actin-like atpase domain, askha superfamily of phosphotransferase, acetokinase, atp binding, phosphotransferase, transferase
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium
• 細胞内の位置: Cytoplasm (By similarity): P63411
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90552.88

構造登録者

Chittori, S.,Savithri, H.S.,Murthy, M.R.N. (登録日: 2011-06-22, 公開日: 2012-08-29, 最終更新日: 2024-10-30)

主引用文献

Chittori, S.,Savithri, H.S.,Murthy, M.R.N.
Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface
Bmc Struct.Biol., 12:24-24, 2012

PubMed Abstract: Bacteria such as Escherichia coli and Salmonella typhimurium can utilize acetate as the sole source of carbon and energy. Acetate kinase (AckA) and phosphotransacetylase (Pta), key enzymes of acetate utilization pathway, regulate flux of metabolites in glycolysis, gluconeogenesis, TCA cycle, glyoxylate bypass and fatty acid metabolism.

PubMed: 23031654
DOI: 10.1186/1472-6807-12-24

実験手法

X-RAY DIFFRACTION (1.9 Å)