3SK2

Crystal structure of phenazine resistance protein EhpR from Enterobacter agglomerans (Erwinia herbicola, Pantoea agglomerans) Eh1087 in complex with griseoluteic acid

3SK2 の概要

• エントリーDOI: 10.2210/pdb3sk2/pdb
• 分子名称: EhpR, 6-formyl-9-methoxyphenazine-1-carboxylic acid (3 entities in total)
• 機能のキーワード: antibiotic resistance, griseoluteate-binding protein
• 由来する生物種: Pantoea agglomerans (Erwinia herbicola)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30126.13

構造登録者

Blankenfeldt, W.,Yu, S. (登録日: 2011-06-22, 公開日: 2011-08-31, 最終更新日: 2024-04-03)

主引用文献

Yu, S.,Vit, A.,Devenish, S.,Mahanty, H.K.,Itzen, A.,Goody, R.S.,Blankenfeldt, W.
Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin / mitomycin C resistance in other bacteria.
Bmc Struct.Biol., 11:33-33, 2011

PubMed Abstract: The phenazines are redox-active secondary metabolites that a large number of bacterial strains produce and excrete into the environment. They possess antibiotic activity owing to the fact that they can reduce molecular oxygen to toxic reactive oxygen species. In order to take advantage of this activity, phenazine producers need to protect themselves against phenazine toxicity. Whereas it is believed that phenazine-producing pseudomonads possess highly active superoxide dismutases and catalases, it has recently been found that the plant-colonizing bacterium Enterobacter agglomerans expresses a small gene ehpR to render itself resistant towards D-alanyl-griseoluteic acid, the phenazine antibiotic produced by this strain.

PubMed: 21849072
DOI: 10.1186/1472-6807-11-33

実験手法

X-RAY DIFFRACTION (1.01 Å)