3SI7

The crystal structure of the NBD1 domain of the mouse CFTR protein, deltaF508 mutant

3SI7 の概要

• エントリーDOI: 10.2210/pdb3si7/pdb
• 分子名称: Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: cystic fibrosis, atp-binding domain, hydrolase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Early endosome membrane; Multi-pass membrane protein (By similarity): P26361
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130441.08

構造登録者

Brautigam, C.A.,Caspa, E.,Thomas, P.J. (登録日: 2011-06-17, 公開日: 2012-02-01, 最終更新日: 2024-02-28)

• 主引用文献: Mendoza, J.L.,Schmidt, A.,Li, Q.,Nuvaga, E.,Barrett, T.,Bridges, R.J.,Feranchak, A.P.,Brautigam, C.A.,Thomas, P.J.; Requirements for efficient correction of DeltaF508 CFTR revealed by analyses of evolved sequences; Cell(Cambridge,Mass.), 148:164-174, 2012; PubMed: 22265409; DOI: 10.1016/j.cell.2011.11.023

実験手法

X-RAY DIFFRACTION (2.25 Å)