3SH8
Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cephaloridine
Replaces: 3KGOSummary for 3SH8
Entry DOI | 10.2210/pdb3sh8/pdb |
Related | 3SH7 3SH9 |
Descriptor | Beta-lactamase, 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | beta-lactamase, fluorophore, cephaloridine, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Bacillus licheniformis |
Cellular location | Cell membrane; Lipid-anchor (Probable): P00808 |
Total number of polymer chains | 2 |
Total formula weight | 59976.16 |
Authors | Wong, W.-T.,Zhao, Y.-X.,Leung, Y.-C. (deposition date: 2011-06-16, release date: 2011-07-27, Last modification date: 2024-03-20) |
Primary citation | Wong, W.-T.,Chan, K.-C.,So, P.-K.,Yap, H.-K.,Chung, W.-H.,Leung, Y.-C.,Wong, K.-Y.,Zhao, Y.-X. Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics J.Biol.Chem., 286:31771-31780, 2011 Cited by PubMed: 21705325DOI: 10.1074/jbc.M110.198895 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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