Crystal structure of broadly and potently neutralizing antibody VRC03 in complex with HIV-1 gp120

Summary for 3SE8

DescriptorHIV-1 Clade AE strain 93TH057 gp120, Heavy chain of antibody VRC03, Light chain of antibody VRC03, ... (8 entities in total)
Functional Keywordshiv, gp120, antibody, vrc03, neutralization, vaccine, envelope glycoprotein, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains3
Total molecular weight91100.83
Kwong, P.D.,Zhou, T. (deposition date: 2011-06-10, release date: 2011-08-10, Last modification date: 2012-08-15)
Primary citation
Wu, X.,Zhou, T.,Zhu, J.,Zhang, B.,Georgiev, I.,Wang, C.,Chen, X.,Longo, N.S.,Louder, M.,McKee, K.,O'Dell, S.,Perfetto, S.,Schmidt, S.D.,Shi, W.,Wu, L.,Yang, Y.,Yang, Z.Y.,Yang, Z.,Zhang, Z.,Bonsignori, M.,Crump, J.A.,Kapiga, S.H.,Sam, N.E.,Haynes, B.F.,Simek, M.,Burton, D.R.,Koff, W.C.,Doria-Rose, N.A.,Connors, M.,Mullikin, J.C.,Nabel, G.J.,Roederer, M.,Shapiro, L.,Kwong, P.D.,Mascola, J.R.
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
Science, 333:1593-1602, 2011
PubMed: 21835983 (PDB entries with the same primary citation)
DOI: 10.1126/science.1207532
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.229700.3%9.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution