3SD5

Crystal Structure of PI3K gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine

Summary for 3SD5

• Entry DOI: 10.2210/pdb3sd5/pdb
• Related: 3P2B
• Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine (3 entities in total)
• Functional Keywords: lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P48736
• Total number of polymer chains: 1
• Total formula weight: 111166.56

Authors

Knapp, M.S.,Elling, R.A. (deposition date: 2011-06-08, release date: 2012-01-04, Last modification date: 2023-09-13)

• Primary citation: Maira, S.M.,Pecchi, S.,Huang, A.,Burger, M.,Knapp, M.,Sterker, D.,Schnell, C.,Guthy, D.,Nagel, T.,Wiesmann, M.,Brachmann, S.,Fritsch, C.,Dorsch, M.,Chene, P.,Shoemaker, K.,De Pover, A.,Menezes, D.,Martiny-Baron, G.,Fabbro, D.,Wilson, C.J.,Schlegel, R.,Hofmann, F.,Garcia-Echeverria, C.,Sellers, W.R.,Voliva, C.F.; Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor.; Mol.Cancer Ther., 11:317-328, 2012; PubMed: 22188813; DOI: 10.1158/1535-7163.MCT-11-0474

Experimental method

X-RAY DIFFRACTION (3.2 Å)