3SD5

Crystal Structure of PI3K gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine

3SD5 の概要

• エントリーDOI: 10.2210/pdb3sd5/pdb
• 関連するPDBエントリー: 3P2B
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine (3 entities in total)
• 機能のキーワード: lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111166.56

構造登録者

Knapp, M.S.,Elling, R.A. (登録日: 2011-06-08, 公開日: 2012-01-04, 最終更新日: 2023-09-13)

• 主引用文献: Maira, S.M.,Pecchi, S.,Huang, A.,Burger, M.,Knapp, M.,Sterker, D.,Schnell, C.,Guthy, D.,Nagel, T.,Wiesmann, M.,Brachmann, S.,Fritsch, C.,Dorsch, M.,Chene, P.,Shoemaker, K.,De Pover, A.,Menezes, D.,Martiny-Baron, G.,Fabbro, D.,Wilson, C.J.,Schlegel, R.,Hofmann, F.,Garcia-Echeverria, C.,Sellers, W.R.,Voliva, C.F.; Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor.; Mol.Cancer Ther., 11:317-328, 2012; PubMed: 22188813; DOI: 10.1158/1535-7163.MCT-11-0474

実験手法

X-RAY DIFFRACTION (3.2 Å)