3SAY

Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142

3SAY の概要

• エントリーDOI: 10.2210/pdb3say/pdb
• 分子名称: Glycogen synthase kinase-3 beta, (3Z)-N,N-diethyl-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, MALONIC ACID, ... (6 entities in total)
• 機能のキーワード: kinase, atp hydrolysis, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P49841
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97654.49

構造登録者

Mazanetz, M.P.,Cheng, R.K.Y.,Rowan, F.,Laughton, C.A.,Barker, J.J.,Fischer, P.M. (登録日: 2011-06-03, 公開日: 2012-06-13, 最終更新日: 2023-12-06)

• 主引用文献: Cheng, R.K.Y.,Rowan, F.,Barker, J.J.; Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142; To be Published,

実験手法

X-RAY DIFFRACTION (2.231 Å)