3SAD

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor

3SAD の概要

• エントリーDOI: 10.2210/pdb3sad/pdb
• 関連するPDBエントリー: 1N8I 1N8W 2GQ3 3S9I 3S9Z 3SAZ 3SB0
• 分子名称: Malate synthase G, MAGNESIUM ION, 4-(2-methylphenyl)-2,4-dioxobutanoic acid, ... (4 entities in total)
• 機能のキーワード: inhibitor complex, structural genomics, mycobacterium tuberculosis structural proteomics project, xmtb, malate synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 80735.84

構造登録者

Krieger, I.V.,Sun, Q.,Sacchettini, J.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (登録日: 2011-06-02, 公開日: 2012-11-07, 最終更新日: 2023-09-13)

• 主引用文献: Krieger, I.V.,Freundlich, J.S.,Gawandi, V.B.,Roberts, J.P.,Gawandi, V.B.,Sun, Q.,Owen, J.L.,Fraile, M.T.,Huss, S.I.,Lavandera, J.L.,Ioerger, T.R.,Sacchettini, J.C.; Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.; Chem.Biol., 19:1556-1567, 2012; PubMed: 23261599; DOI: 10.1016/j.chembiol.2012.09.018

実験手法

X-RAY DIFFRACTION (1.82 Å)