3S7A

Human dihydrofolate reductase binary complex with PT684

3S7A の概要

• エントリーDOI: 10.2210/pdb3s7a/pdb
• 分子名称: Dihydrofolate reductase, SULFATE ION, 4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid, ... (4 entities in total)
• 機能のキーワード: single polypeptide chain, reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22299.33

構造登録者

Cody, V.,Pace, J.,Nowak, J. (登録日: 2011-05-26, 公開日: 2011-10-05, 最終更新日: 2023-09-13)

• 主引用文献: Cody, V.,Pace, J.,Nowak, J.; Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode.; Acta Crystallogr.,Sect.D, 67:875-880, 2011; PubMed: 21931219; DOI: 10.1107/S0907444911030071

実験手法

X-RAY DIFFRACTION (1.8 Å)