3S79

Human placental aromatase cytochrome P450 (CYP19A1) refined at 2.75 angstrom

Summary for 3S79

Related3S7S
DescriptorCytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE, ... (5 entities in total)
Functional Keywordsoxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Peripheral membrane protein P11511
Total number of polymer chains1
Total molecular weight59142.67
Authors
Ghosh, D. (deposition date: 2011-05-26, release date: 2012-06-06, Last modification date: 2017-11-08)
Primary citation
Ghosh, D.,Lo, J.,Morton, D.,Valette, D.,Xi, J.,Griswold, J.,Hubbell, S.,Egbuta, C.,Jiang, W.,An, J.,Davies, H.M.
Novel aromatase inhibitors by structure-guided design.
J.Med.Chem., 55:8464-8476, 2012
PubMed: 22951074 (PDB entries with the same primary citation)
DOI: 10.1021/jm300930n
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23980.2%10.8%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution