3S5L

Crystal structure of CD4 mutant bound to HLA-DR1

Summary for 3S5L

• Entry DOI: 10.2210/pdb3s5l/pdb
• Related: 3S4S
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen DR beta chain, HA peptide, ... (6 entities in total)
• Functional Keywords: protein-protein complex, immune system, co-receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 D7RIG0 3S5L
• Total number of polymer chains: 8
• Total formula weight: 133883.16

Authors

Li, Y. (deposition date: 2011-05-23, release date: 2011-09-21, Last modification date: 2023-09-13)

• Primary citation: Wang, X.X.,Li, Y.,Yin, Y.,Mo, M.,Wang, Q.,Gao, W.,Wang, L.,Mariuzza, R.A.; Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.; Proc.Natl.Acad.Sci.USA, 108:15960-15965, 2011; PubMed: 21900604; DOI: 10.1073/pnas.1109438108

Experimental method

X-RAY DIFFRACTION (2.1 Å)