3S41

Glucokinase in complex with activator and glucose

3S41 の概要

• エントリーDOI: 10.2210/pdb3s41/pdb
• 分子名称: Glucokinase, alpha-D-glucopyranose, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: diabetes mellitus, disease mutation, glycolysis, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53574.71

構造登録者

Liu, S. (登録日: 2011-05-18, 公開日: 2011-09-14, 最終更新日: 2023-09-13)

• 主引用文献: Pfefferkorn, J.A.,Guzman-Perez, A.,Oates, P.J.,Litchfield, J.,Aspnes, G.,Basak, A.,Benbow, J.,Berliner, M.A.,Bian, J.,Choi, C.,Freeman-Cook, K.,Corbett, J.W.,Didiuk, M.,Dunetz, J.R.,Filipski, K.J.,Hungerford, W.M.,Jones, C.S.,Karki, K.,Ling, A.,Li, J.-C.,Patel, L.,Perreault, C.,Risley, H.,Saenz, J.,Song, W.,Tu, M.,Aiello, R.,Atkinson, K.,Barucci, N.,Beebe, D.,Bourassa, P.,Bourbounais, F.,Brodeur, A.M.,Burbey, R.,Chen, J.,D'Aquila, T.,Derksen, D.R.,Haddish-Berhane, N.,Huang, C.,Landro, J.,Lapworth, A.L.,MacDougall, M.,Perregaux, D.,Pettersen, J.,Robertson, A.,Tan, B.,Treadway, J.L.,Liu, S.,Qiu, X.,Knafels, J.,Ammirati, M.,Song, X.,DaSilva-Jardine, P.,Liras, S.,Sweet, L.,Rolph, T.P.; Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus; MEDCHEMCOMM, 2:828-839, 2011; DOI: 10.1039/C1MD00116G

実験手法

X-RAY DIFFRACTION (2.18 Å)