3S0N

Crystal Structure of Human Chymase with Benzimidazolone Inhibitor

3S0N の概要

• エントリーDOI: 10.2210/pdb3s0n/pdb
• 分子名称: Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• 機能のキーワード: serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25880.14

構造登録者

Qian, K.C.,Farrow, N.A.,Padyana, A.K. (登録日: 2011-05-13, 公開日: 2011-07-20, 最終更新日: 2023-09-13)

• 主引用文献: Lo, H.Y.,Nemoto, P.A.,Kim, J.M.,Hao, M.H.,Qian, K.C.,Farrow, N.A.,Albaugh, D.R.,Fowler, D.M.,Schneiderman, R.D.,Michael August, E.,Martin, L.,Hill-Drzewi, M.,Pullen, S.S.,Takahashi, H.,De Lombaert, S.; Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P(1)) region.; Bioorg.Med.Chem.Lett., 21:4533-4539, 2011; PubMed: 21733690; DOI: 10.1016/j.bmcl.2011.05.126

実験手法

X-RAY DIFFRACTION (1.95 Å)