3RX2
Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone
Summary for 3RX2
Entry DOI | 10.2210/pdb3rx2/pdb |
Related | 3RX3 3RX4 |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]ethanoic acid, ... (4 entities in total) |
Functional Keywords | aldose reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 39185.51 |
Authors | |
Primary citation | Zheng, X.,Zhang, L.,Zhai, J.,Chen, Y.,Luo, H.,Hu, X. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase Febs Lett., 586:55-59, 2012 Cited by PubMed: 22155003DOI: 10.1016/j.febslet.2011.11.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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