3RWP

Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1)

Summary for 3RWP

Entry DOI	10.2210/pdb3rwp/pdb
Related	3RWQ 3SC1
Descriptor	3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywords	kinase domain, transferase, phosphoserine: sep, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	37018.09
Authors	Greasley, S.E.,Hickey, M.,Ferre, R.-A.,Krauss, M.,Cronin, C. (deposition date: 2011-05-09, release date: 2011-11-16, Last modification date: 2017-11-08)
Primary citation	Murphy, S.T.,Alton, G.,Bailey, S.,Baxi, S.M.,Burke, B.J.,Chappie, T.A.,Ermolieff, J.,Ferre, R.,Greasley, S.,Hickey, M.,Humphrey, J.,Kablaoui, N.,Kath, J.,Kazmirski, S.,Kraus, M.,Kupchinsky, S.,Li, J.,Lingardo, L.,Marx, M.A.,Richter, D.,Tanis, S.P.,Tran, K.,Vernier, W.,Xie, Z.,Yin, M.J.,Yu, X.H. Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1). J.Med.Chem., 54:8490-8500, 2011 Cited by PubMed: 22040023 DOI: 10.1021/jm201019k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation