3RVG

Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor

3RVG の概要

• エントリーDOI: 10.2210/pdb3rvg/pdb
• 分子名称: Tyrosine-protein kinase JAK2, 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide (3 entities in total)
• 機能のキーワード: tyrosine kinase, janus kinase 2, enzyme inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : O60674
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36184.25

構造登録者

Lim, J.,Taoka, B.,Otte, R.D.,Spencer, K.,Dinsmore, C.J.,Altman, M.D.,Chan, G.,Rosenstein, C.,Sharma, S.,Su, H.P.,Szewczak, A.A.,Xu, L.,Yin, H.,Zugay-Murphy, J.,Marshall, C.G.,Young, J.R. (登録日: 2011-05-06, 公開日: 2012-03-21, 最終更新日: 2017-11-08)

• 主引用文献: Lim, J.,Taoka, B.,Otte, R.D.,Spencer, K.,Dinsmore, C.J.,Altman, M.D.,Chan, G.,Rosenstein, C.,Sharma, S.,Su, H.P.,Szewczak, A.A.,Xu, L.,Yin, H.,Zugay-Murphy, J.,Marshall, C.G.,Young, J.R.; Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.; J.Med.Chem., 54:7334-7349, 2011; PubMed: 21942426; DOI: 10.1021/jm200909u

実験手法

X-RAY DIFFRACTION (2.498 Å)