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3RVB

The structure of HCV NS3 helicase (Heli-80) bound with inhibitor ITMN-3479

3RVB の概要
エントリーDOI10.2210/pdb3rvb/pdb
分子名称RNA helicase, {1-[(5-chloro-2-methyl-1-benzothiophen-3-yl)methyl]-6-(3,5-diaminophenyl)-1H-indol-3-yl}acetic acid, MAGNESIUM ION, ... (5 entities in total)
機能のキーワードhelicase, atp hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Hepatitis C virus (HCV)
細胞内の位置Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
タンパク質・核酸の鎖数1
化学式量合計53370.77
構造登録者
Mather, O.,Cheng, R.,Schonfield, D.,Barker, J. (登録日: 2011-05-06, 公開日: 2014-09-24, 最終更新日: 2024-02-28)
主引用文献Mather, O.,Cheng, R.,Schonfield, D.,Barker, J.
The structure of HCV NS3 helicase with inhibitor ITMN-3479
To be Published,
実験手法
X-RAY DIFFRACTION (2.2 Å)
構造検証レポート
Validation report summary of 3rvb
検証レポート(詳細版)ダウンロードをダウンロード

221051

件を2024-06-12に公開中

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