3RV6

Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group

3RV6 の概要

• エントリーDOI: 10.2210/pdb3rv6/pdb
• 関連するPDBエントリー: 3RV7 3RV8 3RV9
• 分子名称: Isochorismate synthase/isochorismate-pyruvate lyase mbtI, 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: structural genomics, tb structural genomics consortium, tbsgc, salicylate synthase, chorismate binding, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99204.33

構造登録者

Chi, G.,Bulloch, E.M.M.,Manos-Turvey, A.,Payne, R.J.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2011-05-06, 公開日: 2012-05-09, 最終更新日: 2024-03-20)

• 主引用文献: Chi, G.,Manos-Turvey, A.,O'Connor, P.D.,Johnston, J.M.,Evans, G.L.,Baker, E.N.,Payne, R.J.,Lott, J.S.,Bulloch, E.M.; Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis; Biochemistry, 51:4868-4879, 2012; PubMed: 22607697; DOI: 10.1021/bi3002067

実験手法

X-RAY DIFFRACTION (2.04 Å)