3RSR
Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase
Summary for 3RSR
Entry DOI | 10.2210/pdb3rsr/pdb |
Related | 2CVS 2CVU 2CVV 2CVW 2CVX 2CVY |
Descriptor | Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE, ... (4 entities in total) |
Functional Keywords | 10-stranded alpha/beta barrel, nucleotide reduction, oxidized, oxidoreductase |
Biological source | Saccharomyces cerevisiae (yeast) |
Cellular location | Cytoplasm: P21524 |
Total number of polymer chains | 1 |
Total formula weight | 100215.49 |
Authors | Wan, Q.,Mohammed, F.,Jha, S.,Motea, E.,Berdis, A.,Dealwis, C.G. (deposition date: 2011-05-02, release date: 2012-11-14) |
Primary citation | Ahmad, M.F.,Wan, Q.,Jha, S.,Motea, E.,Berdis, A.,Dealwis, C. Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Mol.Cancer Ther., 11:2077-2086, 2012 Cited by PubMed: 22933704DOI: 10.1158/1535-7163.MCT-12-0199 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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