3RSR

Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase

3RSR の概要

• エントリーDOI: 10.2210/pdb3rsr/pdb
• 関連するPDBエントリー: 2CVS 2CVU 2CVV 2CVW 2CVX 2CVY
• 分子名称: Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE, ... (4 entities in total)
• 機能のキーワード: 10-stranded alpha/beta barrel, nucleotide reduction, oxidized, oxidoreductase
• 由来する生物種: Saccharomyces cerevisiae (yeast)
• 細胞内の位置: Cytoplasm: P21524
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100215.49

構造登録者

Wan, Q.,Mohammed, F.,Jha, S.,Motea, E.,Berdis, A.,Dealwis, C.G. (登録日: 2011-05-02, 公開日: 2012-11-14)

• 主引用文献: Ahmad, M.F.,Wan, Q.,Jha, S.,Motea, E.,Berdis, A.,Dealwis, C.; Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase.; Mol.Cancer Ther., 11:2077-2086, 2012; PubMed: 22933704; DOI: 10.1158/1535-7163.MCT-12-0199

実験手法

X-RAY DIFFRACTION (2.3 Å)