3RQP

Structure of the endothelial nitric oxide synthase heme domain in complex with 6-{[(3R,4R)-4-(2-{[(2R/2S)-1-(3-fluorophenyl)propan-2-yl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine

3RQP の概要

• エントリーDOI: 10.2210/pdb3rqp/pdb
• 関連するPDBエントリー: 3RQJ 3RQK 3RQL 3RQM 3RQN 3RQO
• 分子名称: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
• 機能のキーワード: oxidoreductase, enzyme-inhibitor complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• 細胞内の位置: Cell membrane : P29473
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102378.21

構造登録者

Li, H.,Delker, S.L.,Poulos, T.L. (登録日: 2011-04-28, 公開日: 2012-05-02, 最終更新日: 2023-09-13)

• 主引用文献: Li, H.,Xue, F.,Kraus, J.M.,Ji, H.,Labby, K.J.,Mataka, J.,Delker, S.L.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.; Bioorg.Med.Chem., 21:1333-1343, 2013; PubMed: 23352768; DOI: 10.1016/j.bmc.2012.12.019

実験手法

X-RAY DIFFRACTION (2.35 Å)