3RO5

Crystal structure of influenza A virus nucleoprotein with ligand

3RO5 の概要

• エントリーDOI: 10.2210/pdb3ro5/pdb
• 分子名称: Nucleocapsid protein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl][3-(2-methoxyphenyl)-5-methyl-1,2-oxazol-4-yl]methanone (3 entities in total)
• 機能のキーワード: influenza nucleoprotein, viral protein
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114525.85

構造登録者

Pearce, B.C.,Edavettal, S.,McDonnell, P.A.,Lewis, H.A.,Steinbacher, S.,Baldwin, E.T.,Langley, D.R.,Maskos, K.,Mortl, M.,Kiefersauer, R. (登録日: 2011-04-25, 公開日: 2011-09-14, 最終更新日: 2024-02-28)

• 主引用文献: Gerritz, S.W.,Cianci, C.,Kim, S.,Pearce, B.C.,Deminie, C.,Discotto, L.,McAuliffe, B.,Minassian, B.F.,Shi, S.,Zhu, S.,Zhai, W.,Pendri, A.,Li, G.,Poss, M.A.,Edavettal, S.,McDonnell, P.A.,Lewis, H.A.,Maskos, K.,Mortl, M.,Kiefersauer, R.,Steinbacher, S.,Baldwin, E.T.,Metzler, W.,Bryson, J.,Healy, M.D.,Philip, T.,Zoeckler, M.,Schartman, R.,Sinz, M.,Leyva-Grado, V.H.,Hoffmann, H.H.,Langley, D.R.,Meanwell, N.A.,Krystal, M.; Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.; Proc.Natl.Acad.Sci.USA, 108:15366-15371, 2011; PubMed: 21896751; DOI: 10.1073/pnas.1107906108

実験手法

X-RAY DIFFRACTION (2.66 Å)