3RO4
X-ray Structure of Ketohexokinase in complex with an indazole compound derivative
Summary for 3RO4
Entry DOI | 10.2210/pdb3ro4/pdb |
Related | 3NBV 3NBW 3NC2 3NC9 3NCA |
Descriptor | Ketohexokinase, SULFATE ION, 3-ethyl-6-[(3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-1-phenyl-1H-indazole, ... (4 entities in total) |
Functional Keywords | kinase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 68677.74 |
Authors | Abad, M.C.,Gibbs, A.C. (deposition date: 2011-04-25, release date: 2011-08-03, Last modification date: 2023-09-13) |
Primary citation | Zhang, X.,Song, F.,Kuo, G.H.,Xiang, A.,Gibbs, A.C.,Abad, M.C.,Sun, W.,Kuo, L.C.,Sui, Z. Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors. Bioorg.Med.Chem.Lett., 21:4762-4767, 2011 Cited by PubMed: 21767952DOI: 10.1016/j.bmcl.2011.06.067 PDB entries with the same primary citation |
Experimental method |
Structure validation
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