3RIY

Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase

Summary for 3RIY

Related3RIG
DescriptorNAD-dependent deacetylase sirtuin-5, peptide of histone 3 N-succinyl lysine 9, ZINC ION, ... (5 entities in total)
Functional Keywordsdesuccinylase, demalonylase, posttranslational modification, zn-binding domain, rossmann fold domain, hydrolase
Biological sourceHomo sapiens (human)
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Cellular locationMitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion  Q9NXA8
Total number of polymer chains4
Total molecular weight63478.23
Authors
Zhou, Y.,Hao, Q. (deposition date: 2011-04-14, release date: 2011-11-23, Last modification date: 2017-11-08)
Primary citation
Du, J.,Zhou, Y.,Su, X.,Yu, J.J.,Khan, S.,Jiang, H.,Kim, J.,Woo, J.,Kim, J.H.,Choi, B.H.,He, B.,Chen, W.,Zhang, S.,Cerione, R.A.,Auwerx, J.,Hao, Q.,Lin, H.
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
Science, 334:806-809, 2011
PubMed: 22076378 (PDB entries with the same primary citation)
DOI: 10.1126/science.1207861
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.55 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.189501.4%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 3riy
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More Biological unit images

Molmil generated image of 3riy
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Molmil generated image of 3riy
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3riy.pdb1.gz [107.79 KB])
Coordinate files for Biological unit (3riy.pdb2.gz [108.37 KB])