3RIK

The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease

3RIK の概要

• エントリーDOI: 10.2210/pdb3rik/pdb
• 関連するPDBエントリー: 3RIL
• 分子名称: Glucosylceramidase, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: tim-barrel, lysosomal hydrolase, hydrolase, glycosylation, lysosome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 227126.09

構造登録者

Orwig, S.D.,Lieberman, R.L. (登録日: 2011-04-13, 公開日: 2012-03-14, 最終更新日: 2020-07-29)

• 主引用文献: Orwig, S.D.,Tan, Y.L.,Grimster, N.P.,Yu, Z.,Powers, E.T.,Kelly, J.W.,Lieberman, R.L.; Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease; Biochemistry, 50:10647-10657, 2011; PubMed: 22047104; DOI: 10.1021/bi201619z

実験手法

X-RAY DIFFRACTION (2.48 Å)