3RI5

C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin

Summary for 3RI5

• Entry DOI: 10.2210/pdb3ri5/pdb
• Related: 3RHW
• Descriptor: Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, Mouse monoclonal Fab fragment, heavy chain, ... (10 entities in total)
• Functional Keywords: membrane protein, transport protein, cys-loop receptor, ligand-gated ion channel, neurotransmitter receptor, ivermectin, picrotoxin, glycosylation, transport protein-immune system complex, transport protein/immune system
• Biological source: Caenorhabditis elegans (nematode); More
• Total number of polymer chains: 15
• Total formula weight: 438280.31

Authors

Hibbs, R.E.,Gouaux, E. (deposition date: 2011-04-12, release date: 2011-05-25, Last modification date: 2023-09-13)

• Primary citation: Hibbs, R.E.,Gouaux, E.; Principles of activation and permeation in an anion-selective Cys-loop receptor.; Nature, 474:54-60, 2011; PubMed: 21572436; DOI: 10.1038/nature10139

Experimental method

X-RAY DIFFRACTION (3.4 Å)